Oversight by the IACUC starts with the IACUC protocol. Through the protocol review process, the IACUC draws upon the collective experience of its members to advise PIs on project feasibility in addition to regulatory compliance issues related to the PI’s intended animal use. The IACUC meets twice each month to review protocol submissions.
Protocol Synopsis Forms, when submitted to the IACUC by the submission deadline will be reviewed during that month.
Following a pre–review meeting mid–month, the committee will send a list of questions/stipulations to be addressed by the PI. The PI has approximately one week to address these questions/stipulations before the full committee meeting.
If all questions and stipulations are answered to the committee’s satisfaction, committee approval will be granted, notification of external agencies will take place, and animal work can begin.
Administrators and staff have been instructed not to release funds or process animal orders unless an approval protocol number or verification is present and all stipulations attached to the protocol have been addressed.
Even though you may be approved for a multiple year project, the IACUC must review each protocol on an annual basis as required by federal regulations. You will be sent a reminder two months before the anniversary of the original approval date. Updated information and any changes in the animal use protocol must be supplied on the Continuing Review form. Approvals will be extended for another year if there are no major changes in the protocol.
If there are any changes to the protocol during the course of the research project or upon annual renewal, an amendment should be submitted to the IACUC for approval using the Continuing Review form.
The following minor changes to an approved animal use and care protocol can be submitted to the IACUC in the form of an amendment:
The following major changes generally require a submission of the entire protocol (a completed Protocol Synopsis Form) for IACUC approval.
The IACUC reserves the right to request a full protocol if deemed necessary for any protocol.
The Public Health Service policy requires a complete review of activities every three years. To do this, a completed Protocol Synopsis form must be submitted and approved by the IACUC.